Excedrin Extra Strength Pain Relief Caplets provide clinically proven headache relief fast. Excedrin works in 3 ways to relieve headaches: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect. Available in convenient caplet form, this nonprescription pain relief medicine works as hard as you do, combining aspirin and acetaminophen with caffeine. These active ingredients create a powerful formula with two pain relievers and a booster to offer temporary relief of pain from headaches, colds, premenstrual and menstrual cramps, arthritis, tooth pain and muscle pain. For some, headache pain relief with this Excedrin extra strength pain reliever can start in 15 minutes. Get headache relief fast with Excedrin, the headache expert.